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Article

Analysis of the CDR3 length repertoire and the diversity of T cell receptor α and β chains in swine CD4+ and CD8+ T lymphocytes.

Molecular medicine reports - 1 Jul 2017

Wang Chun-Yan, Fang Yong-Xiang, Chen Guo-Hua, Jia Huai-Jie, Zeng Shuang, He Xiao-Bing, Feng Yuan, Li Shou-Jie, Jin Qi-Wang, Cheng Wen-Yu, Jing Zhi-Zhong

Abstract excerpt

The T cell receptor (TCR) is a complex heterodimer that recognizes fragments of antigens as peptides and binds to major histocompatibility complex molecules. The TCR α and β chains possess three hypervariable regions termed complementarity determining regions (CDR1, 2 and 3). CDR3 is responsible for recognizing processed antigen peptides. Immunoscope spectratyping is a simple technique for analyzing CDR3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 28534993
DOI: 10.3892/mmr.2017.6601
PMCID: PMC5482108

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