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Article

Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes.

Frontiers in immunology - 1 Jan 2025

Zhao Haidong, Tang Xiaoqin, Zhang Yuelang, Wu Mingli

Abstract excerpt

Introduction: Cattle produce a unique antibody repertoire characterized by an exceptionally wide range of complementarity determining region 3 heavy chain (CDR3H) lengths, spanning from 1 bp to 204 bp-a feature that is extremely rare among mammals. The diversity characteristics of CDR3 segments of varying lengths and the underlying genetic and structural mechanisms remain an active area of research. Methods: We...

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Identifiers

PMID: 41532095
DOI: 10.3389/fimmu.2025.1722984
PMCID: PMC12791044

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