Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonsense suppression in thymine-requiring strains of Escherichia coli is a consequence of altered folate metabolism.

Molecular & general genetics : MGG - 1 Apr 1993

Basso J, Tiganos E, Herrington M B

Abstract excerpt

Thymine-requiring strains of Escherichia coli suppress nonsense and frameshift mutants of T4 phage. We proposed that these mutants make errors during translation because of an imbalance in folate metabolism. A thymine-requiring strain grown under suppressing conditions has elevated levels of reduced folates. We tested the effect of either mutational blocks or the inhibition of various steps in folate biosynthesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli
Share to Genes, Bacterial
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Plasmids

Share to Promoter Regions, Genetic

Share to Protein Biosynthesis

Share to Species Specificity

Source

Identifiers

PMID: 8479427
DOI: 10.1007/BF00279550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Nonsense suppression in thymine-requiring strains of Escherichia coli is a consequence of altered folate metabolism.PMID 8479427Read ↗

Modification of the suppressor phenotype of thymine requiring strains of Escherichia coli.Semantic proximity Read ↗

Kasugamycin inhibition of nonsense suppression by thymine-requiring strains of Escherichia coli K12.Semantic proximity Read ↗

Changes in translational accuracy of Escherichia coli when folate metabolism is perturbed.Semantic proximity Read ↗

Growth properties of a folA null mutant of Escherichia coli K12.Semantic proximity Read ↗

Life without dihydrofolate reductase FolA.Semantic proximity Read ↗

Systems metabolic engineering of Bacillus subtilis for efficient biosynthesis of 5‐methyltetrahydrofolateSemantic proximity Read ↗

Synthesis of thiamine in Salmonella typhimurium independent of the purF function.Semantic proximity Read ↗

Mutations in the tryptophan operon allow PurF-independent thiamine synthesis by altering flux in vivo.Semantic proximity Read ↗

A mutation in the folA promoter delays adaptation to minimal medium by Escherichia coli K-12.Semantic proximity Read ↗

Reduced flux through the purine biosynthetic pathway results in an increased requirement for coenzyme A in thiamine synthesis in Salmonella enterica serovar typhimurium.Semantic proximity Read ↗

Effects of deregulation of methionine biosynthesis on methionine excretion in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.