Article
Changes in translational accuracy of Escherichia coli when folate metabolism is perturbed.
Microbios - 1 Jan 1994
Basso J, Herrington M B
Abstract excerpt
Translational accuracy was monitored in Escherichia coli mutants which contain abnormal folate pools. A decrease in translational accuracy was indicated by the increased production of a T4 phage mutant containing a UGA mutation in a tail fibre gene. An E. coli folC mutant suppressed the phage mut...
Topics
- Aminopterin
- Coliphages
- Escherichia coli
- Folic Acid
- Folic Acid Antagonists
- Genes, Bacterial
- Methionine
- Models, Genetic
- Mutation
- Peptide Synthases
- Protein Biosynthesis
- RNA, Transfer, Trp
- Suppression, Genetic
- Tetrahydrofolates
- Thymidylate Synthase