Article
Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia.
Histochemistry and cell biology - 1 May 2015
Rippa Alexandra, Terskikh Vasily, Nesterova Anastasia, Vasiliev Andrey, Vorotelyak Ekaterina
Abstract excerpt
Mice with skin and hair follicle (HF) defects are common models of human skin disorders. A mutant strain with the we/we wal/wal genotype develops alopecia. We found the hair shaft structure in the pelage of mutant mice to have significant defects. Although these mice lose their hair at 21 days, a label-retaining cell population persists in HFs until at least day 54. Depilation-induced anagen was accomplished in...
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