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Article

The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter.

European journal of immunology - 1 Mar 1995

Kim J, Reeves R, Rothman P, Boothby M

Abstract excerpt

The rate of germ-line RNA transcription correlates with the rate of immunoglobulin heavy chain isotype switching. A promoter element for the transcription of RNA from the germ-line mouse immunoglobulin epsilon heavy chain constant region gene is induced by interleukin(IL)-4 and lipopolysaccharide, and is bound at its transcription initiation sites by an IL-4-inducible nuclear protein, NF-BRE. To examine the...

Topics

Animals
Base Sequence
Cell Line
DNA-Binding Proteins
Down-Regulation
Electrophoresis, Polyacrylamide Gel
HMGA1a Protein
High Mobility Group Proteins
Immunoglobulin E
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

RNA, Messenger

Recombinant Proteins

Source

Identifiers

PMID: 7705411
DOI: 10.1002/eji.1830250326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7705411-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter.PMID 7705411Read ↗

The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell ProliferationSemantic proximity Read ↗

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.Semantic proximity Read ↗

NF-Y, a CCAAT box-binding protein, is one of the trans-acting factors necessary for the response of the murine ERp72 gene to protein traffic.Semantic proximity Read ↗

Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.Semantic proximity Read ↗

The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.Semantic proximity Read ↗

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.Semantic proximity Read ↗

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