Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs.

doi:10.1016/0304-3940(93)90099-7

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Article

Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs.

Neuroscience letters - 5 Feb 1993

Buckland P R, O'Donovan M C, McGuffin P

Abstract excerpt

We have investigated the effects of antipsychotic drugs on the expression of the two dopamine D2 receptor splicing variants using multiprobe oligonucleotide solution hybridisation. Both long and short mRNA variants were increased in abundance by approximately 2-fold by both haloperidol and loxapi...

Topics

Alternative Splicing
Analysis of Variance
Animals
Base Sequence
Brain
Genetic Variation
Haloperidol
Loxapine
Male
Molecular Sequence Data
Oligonucleotide Probes
RNA, Messenger
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2
Time Factors
Up-Regulation

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