Article
Genomic analysis and functional expression of canine dopamine D2 receptor.
Gene - 17 Oct 2000
Myeong H, Jeoung D, Kim H, Ha J H, Lee Y, Kim K H, Park C, Kaang B K
Abstract excerpt
Dopamine D2 receptor (DRD2) is one of the five dopamine receptors with seven transmembrane domains that are coupled to the G protein. We have cloned and characterized the genomic and cDNA sequences of the canine DRD2 gene, which are 12.7 and 2.7 kb in size, respectively. The genomic DNA is composed of seven exons and six introns, encoding a 443 amino acid protein with 95% amino acid identity to other mammalian D2...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Northern
- Cloning, Molecular
- DNA
- DNA, Complementary
- Dogs
- Dopamine
- Dose-Response Relationship, Drug
- Female
- Gene Expression
- Genes
- Genotype
- Male
- Membrane Potentials