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Article

Evolutionary conservation of major histocompatibility complex-DR/peptide/T cell interactions in primates.

1 Apr 1993

Abstract excerpt

Many major histocompatibility complex (MHC) polymorphisms originate from ancient structures that predate speciation. As a consequence, members of the Mhc-DRB1*03 allelic lineage are not only present in humans but in chimpanzees and rhesus macaques as well. This emphasizes that Mhc-DRB1*03 members must have been present in a common ancestor of these primate species that lived about 30 million years ago. Due to the...

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Identifiers

PMID: 8459225
DOI: 10.1084/jem.177.4.979

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