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Article

Significant Downregulation of Platelet Gene Expression in Metastatic Lung Cancer

1 Oct 2010

Abstract excerpt

Platelets play a major role in the metastatic dissemination of tumor cells in vivo . Recent evidence reveals megakaryocyte-derived platelet pre-mRNA is spliced to mRNA and then translated into functional proteins in response to external stimulation. Employing a human lung cancer model, we hypothesized a subset of megakaryocyte/platelet genes exists that are significantly over or underexpressed in metastasis...

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PMID: 21500395
DOI: 10.1111/j.1752-8062.2010.00226.x

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