Article

Therapy with Monoclonal Antibodies. II. The Contribution of Fcγ Receptor Binding and the Influence of CH1 and CH3 Domains on In Vivo Effector Function

1998-10-01

Abstract excerpt

Abstract An in vivo model is used to define Fc motifs engaged by mAbs to deplete target cells. Human IgG1 and human IgG4 were very potent, and mutations within a motif critical for FcγR binding (glutamate 233 to proline, leucine/phenylalanine 234 to valine, and leucine 235 to alanine) completely prevented depletion. Mouse IgG2b was also potent, and mutations to prevent complement activation did not impair depletio...

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Literature Corpus work: ac37da9a-412c-57eb-afd4-9ab99e35cf91
DOI: 10.4049/jimmunol.161.8.3862

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