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Article

DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function.

Nature - 4 Feb 1993

Moya M, Roberts D, Novick P

Abstract excerpt

The protein Sec4p plays an essential role at the final stage of the yeast secretory pathway and belongs to the ras superfamily of GTP-binding proteins, more specifically to a branch that includes Ypt1p in Saccharomyces cerevisiae and rab proteins in mammalian cells. GTP-binding proteins change conformation depending on whether GTP or GDP is bound and can thus act as a regulatory switch. The protein remains in its...

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PMID: 8429886
DOI: 10.1038/361460a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function.PMID 8429886Read ↗

Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast.Semantic proximity Read ↗

Multicopy suppression screen in the msb3 msb4 Saccharomyces cerevisiae double mutant, affected in Ypt/RabGAP activity.Semantic proximity Read ↗

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line.Semantic proximity Read ↗

Identification of regulators for Ypt1 GTPase nucleotide cycling.Semantic proximity Read ↗

Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p.Semantic proximity Read ↗

Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis.Semantic proximity Read ↗

Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport.Semantic proximity Read ↗

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.Semantic proximity Read ↗

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.Semantic proximity Read ↗

Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating.Semantic proximity Read ↗

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