DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function.

doi:10.1038/361460a0

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Article

DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function.

Nature - 4 Feb 1993

Moya M, Roberts D, Novick P

Abstract excerpt

The protein Sec4p plays an essential role at the final stage of the yeast secretory pathway and belongs to the ras superfamily of GTP-binding proteins, more specifically to a branch that includes Ypt1p in Saccharomyces cerevisiae and rab proteins in mammalian cells. GTP-binding proteins change co...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA, Fungal
Fungal Proteins
GTP-Binding Proteins
Genes, Suppressor
Guanine Nucleotide Exchange Factors
Guanosine Diphosphate
Guanosine Triphosphate
Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Restriction Mapping

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

rab GTP-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 8429886
DOI: 10.1038/361460a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8429886-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function.PMID 8429886Read ↗

Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast.Semantic proximity Read ↗

Multicopy suppression screen in the msb3 msb4 Saccharomyces cerevisiae double mutant, affected in Ypt/RabGAP activity.Semantic proximity Read ↗

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line.Semantic proximity Read ↗

Identification of regulators for Ypt1 GTPase nucleotide cycling.Semantic proximity Read ↗

Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p.Semantic proximity Read ↗

Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis.Semantic proximity Read ↗

Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport.Semantic proximity Read ↗

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.Semantic proximity Read ↗

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.Semantic proximity Read ↗

Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating.Semantic proximity Read ↗

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