Article
Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op/op) mice by a single injection of macrophage colony-stimulating factor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 1993
Kodama H, Yamasaki A, Abe M, Niida S, Hakeda Y, Kawashima H
Abstract excerpt
Severe deficiency of osteoclasts in op/op mice, caused by the absence of functional macrophage colony-stimulating factor (M-CSF), is cured by daily injections of purified recombinant human M-CSF (rhM-CSF). In this study, we found that a single injection of 5 micrograms rhM-CSF is enough for recru...
Topics
- Animals
- Bone Resorption
- Diphosphonates
- Female
- Macrophage Colony-Stimulating Factor
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Osteoclasts
- Osteopetrosis
- Recombinant Proteins
- Tibia