Article
Macrophage colony-stimulating factor restores bone resorption in op/op bone in vitro in conjunction with parathyroid hormone or 1,25-dihydroxyvitamin D3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 1994
Morohashi T, Corboz V A, Fleisch H, Cecchini M G, Felix R
Abstract excerpt
The in vivo administration of macrophage colony-stimulating factor (M-CSF) restores osteoclastogenesis and bone resorption in the op/op murine osteopetrosis. In vitro, exogenous M-CSF has been shown to be necessary for the generation of osteoclast-like cells in cocultures of hematopoietic and mes...
Topics
- Animals
- Bone Resorption
- Calcitriol
- Calcium
- Cells, Cultured
- Drug Synergism
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
- Interleukin-1
- Macrophage Colony-Stimulating Factor
- Male
- Mice
- Mutation
- Organ Culture Techniques
- Osteoclasts
- Osteopetrosis
- Parathyroid Hormone
- Pregnancy