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Article

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1 Jan 1993

Abstract excerpt

The mechanisms of delayed onset and cell death in Huntington's disease (HD) are unknown. One possibility is that a genetic defect in energy metabolism may result in slow excitotoxic neuronal death. Therefore, we examined the effects of age on striatal lesions produced by local administration of the mitochondrial toxin 3-nitropropionic acid in rats. In vivo chemical shift magnetic resonance imaging showed marked...

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PMID: 8417157
DOI: 10.1111/j.1471-4159.1993.tb05859.x

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Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic AcidPMID 8417157Read ↗

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