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Article

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1 Oct 1993

Abstract excerpt

We have examined DNA from four human esophageal carcinoma cell lines and 50 primary esophageal carcinomas obtained from China, Italy, and France for amplification of the cyclin D1 gene. We also examined 36 of these 50 carcinomas for expression of the cyclin D1 and retinoblastoma (RB) proteins by immunohistochemistry. We found a 3- to 10-fold amplification of the cyclin D1 gene in 16 of the 50 (32%) tumors and in...

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PMID: 8415648
DOI: 10.1073/pnas.90.19.9026

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