Human cyclin D1 oncogene and esophageal squamous cell carcinoma

doi:10.1002/1097-0142(19950815)76:4<541::aid-cncr2820760402>3.0.co;2-i

Article

Human cyclin D1 oncogene and esophageal squamous cell carcinoma

15 Aug 1995

Abstract excerpt

BACKGROUND: Oncogene activation and tumor suppressor gene inactivation have been implicated in the genetic basis of esophageal squamous cell carcinoma (ESCC). Cyclin D1, an oncogene that has a critical role in G1 progression of the cell cycle, has been observed to be amplified in carcinomas of the breast and head and neck, and translocated in parathyroid adenomas and centrocytic lymphomas. METHODS: Established...

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