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Article

TRP-PLIK, a bifunctional protein with kinase and ion channel activities.

Science (New York, N.Y.) - 9 Feb 2001

Runnels L W, Yue L, Clapham D E

Abstract excerpt

We cloned and characterized a protein kinase and ion channel, TRP-PLIK. As part of the long transient receptor potential channel subfamily implicated in control of cell division, it is a protein that is both an ion channel and a protein kinase. TRP-PLIK phosphorylated itself, displayed a wide tissue distribution, and, when expressed in CHO-K1 cells, constituted a nonselective, calcium-permeant, 105-picosiemen,...

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Identifiers

PMID: 11161216
DOI: 10.1126/science.1058519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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