Incidence of tubulostromal adenoma of the ovary in aged germ cell-deficient mice.

Abstract excerpt

Female mice homozygous for the germ cell-deficient (gcd) mutation enter reproductive senescence prematurely due to a dearth of germ cells arising in embryonic development. The ovaries of young gcd/gcd animals are atrophic, composed of little more than stromal cells in a connective tissue matrix. By one year of age, 56 per cent of homozygotes have developed tubulostromal adenoma of the ovary while 100 per cent...

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