Article
A murine skeletal adaptation that significantly increases cortical bone mechanical properties. Implications for human skeletal fragility.
The Journal of clinical investigation - 1 Oct 1993
Bonadio J, Jepsen K J, Mansoura M K, Jaenisch R, Kuhn J L, Goldstein S A
Abstract excerpt
Mov13 mice carry a provirus that prevents transcription initiation of the alpha 1(I) collagen gene. Mutant mice homozygous for the null mutation produce no type I collagen and die at mid-gestation, whereas heterozygotes survive to adulthood. Dermal fibroblasts from heterozygous mice produce approximately 50% less type I collagen than normal littermates, and the partial deficiency in collagen production results in...
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