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Article

Adaptive and injury response of bone to mechanical loading

10 Oct 2012

Abstract excerpt

Bone responds to supraphysiological mechanical loads by increasing bone formation. Depending on the applied strain magnitude (and other loading parameters) the response can be either adaptive (mostly lamellar bone) or injury (mostly woven bone). Seminal studies of Hert, Lanyon, and Rubin originally established the basic "rules" of bone mechanosensitivity. These were reinforced by subsequent studies using...

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PMID: 23505338
DOI: 10.1038/bonekey.2012.192

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