Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease.

doi:10.1006/jmcc.2000.1289

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Article

Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease.

Journal of molecular and cellular cardiology - 1 Jan 2001

Dalloz F, Osinska H, Robbins J

Abstract excerpt

Within the last 10 years via gene targeting and transgenesis, numerous models of cardiovascular disease have been established and used to determine if a protein's presence or absence causes cardiovascular disease. By affecting the heart's protein complement in a defined manner, the function of the different mutated proteins or protein isoforms present in the contractile apparatus can be determined and pathogenic...

Topics

Animals
Animals, Genetically Modified
Cardiomyopathy, Hypertrophic
Cardiovascular Diseases
Carrier Proteins
Contractile Proteins
Disease Models, Animal
Forecasting
Gene Targeting
Genes, Dominant
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypertrophy

Mice

Mice, Knockout

Mice, Mutant Strains

Models, Animal

Mutation

Myocardial Contraction

Source

Open in PubMed

Identifiers

PMID: 11133219
DOI: 10.1006/jmcc.2000.1289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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