Article
Hypomorphic mice.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Baker Darren J
Abstract excerpt
The use of genetically engineered mice has become a standard approach in order to study the physiological contribution of genes in a variety of life-science disciplines. Classical and conditional gene-targeting methods aimed at generating knock-out mice that lack gene products have been useful, but may be limited in their scope. If the gene of interest is essential for cell viability, little insight can be gained...
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