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Article

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB.

Nature - 4 Jan 1996

Barton K, Muthusamy N, Chanyangam M, Fischer C, Clendenin C, Leiden J M

Abstract excerpt

The basic/leucine zipper (bZip) transcription factor, CREB, binds to the CRE element (TGANNTCA). The transcriptional activity of CREB requires phosphorylation of the protein on a serine residue at position 119 (ref. 6). CREs are present in a number of T-cell genes but the precise role of CREB in T-cell differentiation and function was unknown. Here we show that resting thymocytes contain predominantly...

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PMID: 8538746
DOI: 10.1038/379081a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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