Article
pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene.
The EMBO journal - 1 Oct 1993
Espeso E A, Tilburn J, Arst H N, Peñalva M A
Abstract excerpt
Transcription of the ipnA gene encoding isopenicillin N synthetase, an enzyme of secondary metabolism, is under the control of the pH regulatory system in the fungus Aspergillus nidulans. External alkaline pH or mutations in pacC, the wide domain regulatory gene which mediates pH regulation, override carbon regulation of ipnA transcript levels, resulting in elevation of the levels of this message in sucrose...
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