Article
pH regulation of penicillin production in Aspergillus nidulans.
FEMS microbiology letters - 15 Jan 1991
Shah A J, Tilburn J, Adlard M W, Arst H N
Abstract excerpt
As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pa...
Topics
- Aspergillus nidulans
- Chromatography, High Pressure Liquid
- Fermentation
- Genotype
- Hydrogen-Ion Concentration
- Penicillin G
- Penicillins
