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Article

pH regulation of penicillin production in Aspergillus nidulans.

FEMS microbiology letters - 15 Jan 1991

Shah A J, Tilburn J, Adlard M W, Arst H N

Abstract excerpt

As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pacC which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in...

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PMID: 2037230
DOI: 10.1016/0378-1097(91)90553-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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pH regulation of penicillin production in Aspergillus nidulans.PMID 2037230Read ↗

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Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB.Semantic proximity Read ↗

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Regulation of gene expression by ambient pH in filamentous fungi and yeasts.Semantic proximity Read ↗

Alkaliphilic/Alkali-Tolerant Fungi: Molecular, Biochemical, and Biotechnological AspectsSemantic proximity Read ↗

Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans.Semantic proximity Read ↗

Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety.Semantic proximity Read ↗

The pH-induced glycosylation of secreted phosphatases is mediated in Aspergillus nidulans by the regulatory gene pacC-dependent pathway.Semantic proximity Read ↗

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