The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.

doi:10.1038/ng0893-398

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Article

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.

Nature genetics - 1 Aug 1993

Andrew S E, Goldberg Y P, Kremer B, Telenius H, Theilmann J, Adam S, Starr E, Squitieri F, Lin B, Kalchman M A

Abstract excerpt

Huntington's disease (HD) is associated with the expansion of a CAG trinucleotide repeat in a novel gene. We have assessed 360 HD individuals from 259 unrelated families and found a highly significant correlation (r = 0.70, p = 10(-7)) between the age of onset and the repeat length, which account...

Topics

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Base Sequence
Child
Child, Preschool
Cohort Studies
DNA
Female
Genotype
Humans
Huntington Disease
Leukocytes
Male
Middle Aged
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8401589
DOI: 10.1038/ng0893-398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8401589-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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