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Article

A study of the Huntington's disease associated trinucleotide repeat in the Scottish population.

Journal of medical genetics - 1 Dec 1993

Barron L H, Warner J P, Porteous M, Holloway S, Simpson S, Davidson R, Brock D J

Abstract excerpt

Accurate measurements of a specific CAG repeat sequence in the Huntington's disease (HD) gene in 337 HD patients and 229 normal controls from the Scottish population showed a range from 35 to 62 repeats in affected subjects and eight to 33 in normal subjects. A link between early onset of symptoms and very high repeat number was seen. For HD patients with the most common affected allele sizes (39 to 42 repeats)...

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Identifiers

PMID: 8133495
DOI: 10.1136/jmg.30.12.1003
PMCID: PMC1016632

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