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Article

A study of the Huntington's disease associated trinucleotide repeat in the Scottish population.

Journal of medical genetics - 1 Dec 1993

Barron L H, Warner J P, Porteous M, Holloway S, Simpson S, Davidson R, Brock D J

Abstract excerpt

Accurate measurements of a specific CAG repeat sequence in the Huntington's disease (HD) gene in 337 HD patients and 229 normal controls from the Scottish population showed a range from 35 to 62 repeats in affected subjects and eight to 33 in normal subjects. A link between early onset of symptoms and very high repeat number was seen. For HD patients with the most common affected allele sizes (39 to 42 repeats)...

Topics

Adult
Age of Onset
Aged
Alleles
Fathers
Female
Haplotypes
Humans
Huntington Disease
Male
Middle Aged
Mothers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Repetitive Sequences, Nucleic Acid

Scotland

Source

Open in PubMed Open full text

Identifiers

PMID: 8133495
DOI: 10.1136/jmg.30.12.1003
PMCID: PMC1016632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8133495-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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