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Article

Huntington's disease in Grampian region: correlation of the CAG repeat number and the age of onset of the disease.

Journal of medical genetics - 1 Dec 1993

Simpson S A, Davidson M J, Barron L H

Abstract excerpt

The identification of an unstable trinucleotide repeat as the mutation responsible for Huntington's disease (HD) has given the hope that additional information can be provided about age of onset and mode of action of the mutated gene. We present in this paper results of a clinical and molecular study of 82 patients affected with HD from 46 pedigrees within the Grampian region, Scotland. Our results show a...

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Identifiers

PMID: 8133498
DOI: 10.1136/jmg.30.12.1014
PMCID: PMC1016635

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