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Article

Molecular analysis of late onset Huntington's disease.

Journal of medical genetics - 1 Dec 1993

Kremer B, Squitieri F, Telenius H, Andrew S E, Theilmann J, Spence N, Goldberg Y P, Hayden M R

Abstract excerpt

Late onset Huntington's disease is characterised by onset of symptoms after the age of 50 and is usually associated with a milder course. We have analysed the CAG trinucleotide repeat within the HD gene in 133 late onset patients from 107 extended families. The median upper allele size for the CAG repeat was 42 with a range of 38 to 48 repeats. A significant negative correlation (r = -0.29, p = 0.001) was found...

Topics

Age of Onset
Aged
Aged, 80 and over
Alleles
Base Sequence
Cohort Studies
DNA Primers
Fathers
Female
Humans
Huntington Disease
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mothers

Oligodeoxyribonucleotides

Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 8133510
DOI: 10.1136/jmg.30.12.991
PMCID: PMC1016630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8133510-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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