Instability of CAG repeats in Huntington's disease: relation to parental transmission and age of onset.

doi:10.1136/jmg.31.5.377

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Article

Instability of CAG repeats in Huntington's disease: relation to parental transmission and age of onset.

Journal of medical genetics - 1 May 1994

Trottier Y, Biancalana V, Mandel J L

Abstract excerpt

Huntington's disease (HD) has recently been found to be caused by expansion of a trinucleotide (CAG) repeat within the putative coding region of a gene with an unknown function. We report here an analysis of HD mutation and the characteristics of its transmission in 36 HD families. CAG repeats on...

Topics

Adult
Age of Onset
Aged
Analysis of Variance
Female
Gene Expression
Humans
Huntington Disease
Linear Models
Male
Middle Aged
Mutation
Parents
Regression Analysis
Repetitive Sequences, Nucleic Acid
Sex Factors

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