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Article

ProCMD: a database and 3D web resource for protein C mutants.

BMC bioinformatics - 8 Mar 2007

D'Ursi Pasqualina, Marino Francesca, Caprera Andrea, Milanesi Luciano, Faioni Elena M, Rovida Ermanna

Abstract excerpt

BACKGROUND: Activated Protein C (ProC) is an anticoagulant plasma serine protease which also plays an important role in controlling inflammation and cell proliferation. Several mutations of the gene are associated with phenotypic functional deficiency of protein C, and with the risk of developing venous thrombosis. Structure prediction and computational analysis of the mutants have proven to be a valuable aid in...

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Identifiers

PMID: 17430555
DOI: 10.1186/1471-2105-8-S1-S11
PMCID: PMC1885840

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