Article
Correlation between relatives for colorectal cancer mortality in familial adenomatous polyposis.
Annals of human genetics - 1 May 1993
Presciuttini S, Bertario L, Sala P, Rossetti C, Lewontin R C
Abstract excerpt
It has long been realized that age-specific cancer mortality in Familial Adenomatous Polyposis (FAP) was bimodal, and a theory was proposed in which the involved locus was polymorphic in the general population. After the molecular cloning of the region 5q21, it has been suggested that the phenotypic variability in FAP may be due to the interaction of two loci, one of which is polymorphic. We show that these two...
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