Article
Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations.
Annals of human genetics - 1 Oct 1994
Presciuttini S, Varesco L, Sala P, Gismondi V, Rossetti C, Bafico A, Ferrara G B, Bertario L
Abstract excerpt
Heterogeneity among and within FAP pedigrees for the age of symptom onset and the age at death from colorectal cancer was studied in a sample of 583 patients of the Italian Polyposis Registry. The among pedigree variation was largely explained by clustering of families in two groups, 'early FAP'...
Topics
- Adenomatous Polyposis Coli
- Adolescent
- Adult
- Age of Onset
- Aged
- Base Sequence
- Child
- Colorectal Neoplasms
- Female
- Genes, APC
- Genetic Variation
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pedigree