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Article

Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations.

Annals of human genetics - 1 Oct 1994

Presciuttini S, Varesco L, Sala P, Gismondi V, Rossetti C, Bafico A, Ferrara G B, Bertario L

Abstract excerpt

Heterogeneity among and within FAP pedigrees for the age of symptom onset and the age at death from colorectal cancer was studied in a sample of 583 patients of the Italian Polyposis Registry. The among pedigree variation was largely explained by clustering of families in two groups, 'early FAP' (most colorectal cancer deaths below 45 years of age) and 'late FAP' families (most deaths above age 45). The...

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Identifiers

PMID: 7864589
DOI: 10.1111/j.1469-1809.1994.tb00730.x

Genes

FAP
APC

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations.PMID 7864589Read ↗

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