Article
Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence.
Journal of bacteriology - 1 Jul 1993
Roland K L, Martin L E, Esther C R, Spitznagel J K
Abstract excerpt
We isolated spontaneous mutations (pmrA) in the smooth strain Salmonella typhimurium LT2 that show increased resistance to the cationic antibacterial proteins of human neutrophils and to the drug polymyxin B. The mutation in one strain, JKS5, maps to 93 min on the S. typhimurium chromosome, near...
Topics
- Alleles
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Genes, Bacterial
- Molecular Sequence Data
- Mutagenesis
- Mutagenesis, Insertional
- Open Reading Frames
- Phenotype
- Polymyxins
- Salmonella typhimurium
- Sequence Analysis, DNA
- Sequence Deletion