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The effect of PmrA/B two-component system on the phenotype and virulence of Salmonella Typhimurium.

Microbial pathogenesis - 1 Jul 2026

Liu Cunlei, Fang Yupeng, Guo Ziwei, Guo Kuanjia, Zhao Tian, Chen Tiantian, Zhao Qiuyi, Wang Xuyang, Liu Yu, Dou Zhihao, Zhang Xiaoqing, Yang Shunli, Zhang Jie, Liu Yongsheng

Abstract excerpt

To investigate the role of the PmrA/B two-component system in the pathogenicity of Salmonella Typhimurium, this study constructed single-gene deletion mutants of PmrA and PmrB, a double-gene deletion mutant of PmrA/B, and their corresponding complementary strains using the λ-Red homologous recombination system. The biological characteristics of the wild-type strain, mutant strains, and complemented strains were...

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PMID: 41991012
DOI: 10.1016/j.micpath.2026.108506

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