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Article

Antibiotic-Driven Evolutionary Engineering in Salmonella Heidelberg Reveals Genomic Signatures of Attenuation.

Genes - 12 Feb 2026

Chacón Ruy D, Ramírez Manuel, Astolfi-Ferreira Claudete S, Piantino Ferreira Antonio J

Abstract excerpt

Background/Objectives: Salmonella Heidelberg (SH) is a globally distributed pathogen associated with gastrointestinal disease in humans and animals and frequently affects poultry. Among the classic strategies used in vaccine development, evolutionary engineering enables the generation of attenuated bacterial strains through exposure to selective pressures such as antibiotics. In this study, spontaneous...

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Identifiers

PMID: 41751619
DOI: 10.3390/genes17020235
PMCID: PMC12940389

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