Article
Identification of the fusion-from-without determinants of herpes simplex virus type 1 glycoprotein B.
Virology - 6 Jan 1997
Saharkhiz-Langroodi A, Holland T C
Abstract excerpt
Fusion-from-without (FFWO) is the rapid induction of cell fusion at high multiplicities of infection and in the absence of viral protein synthesis. The ANG path strain and several other strains of herpes simplex virus type 1 (HSV-1) effectively cause FFWO of Vero cells. FFWO-inducing strains of HSV-1 contain syncytial mutations in the gB cytoplasmic domain; however, not all strains with such syncytial mutations...
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