Altered pathogenesis in herpes simplex virus type 1 infection due to a syncytial mutation mapping to the carboxy terminus of glycoprotein B.

Abstract excerpt

A syncytial (syn) variant of herpes simplex virus type 1 strain 17 syn+ was selected by serial passage in heparin, a glycosaminoglycan which potently inhibits herpes simplex virus infectivity. This virus, 17 hep syn, is sixfold more heparin resistant than its parent. By using marker transfer techniques, its syn phenotype, but not heparin resistance, was mapped first to the BamHI G fragment (0.343 to 0.415 map...

Topics

• Animals
• Antigens, Viral
• Drug Resistance, Microbial
• Genetic Markers
• Giant Cells
• Heparin
• Kinetics
• Mice
• Mutation
• Organ Specificity
• Rabbits
• Simplexvirus