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Article

A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees.

The Journal of infectious diseases - 1 Apr 1993

Hall S L, Sarris C M, Tierney E L, London W T, Murphy B R

Abstract excerpt

A live attenuated cold-adapted parainfluenza virus type 3 (PIV-3) vaccine is being developed to prevent the serious lower respiratory tract disease caused by this virus in infants and young children. This cold-passaged mutant (cp45) was evaluated in seronegative chimpanzees and found to be highly attenuated in both the upper and lower respiratory tracts compared to its wild-type parent. Animals immunized with...

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Source

Identifiers

PMID: 8383726
DOI: 10.1093/infdis/167.4.958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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