A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees.

doi:10.1093/infdis/167.4.958

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Article

A cold-adapted mutant of parainfluenza virus type 3 is attenuated and protective in chimpanzees.

The Journal of infectious diseases - 1 Apr 1993

Hall S L, Sarris C M, Tierney E L, London W T, Murphy B R

Abstract excerpt

A live attenuated cold-adapted parainfluenza virus type 3 (PIV-3) vaccine is being developed to prevent the serious lower respiratory tract disease caused by this virus in infants and young children. This cold-passaged mutant (cp45) was evaluated in seronegative chimpanzees and found to be highly...

Topics

Adaptation, Physiological
Animals
Cold Temperature
Mutation
Pan troglodytes
Parainfluenza Virus 3, Human
Paramyxoviridae Infections
Phenotype
Vaccines, Attenuated
Viral Vaccines
Virus Replication

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