Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees.

doi:10.1128/jcm.29.6.1175-1182.1991

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Article

Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees.

Journal of clinical microbiology - 1 Jun 1991

Clements M L, Belshe R B, King J, Newman F, Westblom T U, Tierney E L, London W T, Murphy B R

Abstract excerpt

In an attempt to evaluate the level of attenuation of live parainfluenza type 3 virus (PIV3) vaccine candidates, we compared the responses of partially immune adult volunteers inoculated intranasally with 10(6) to 10(7) 50% tissue culture infective dose (TCID50) of bovine PIV3 (n = 18) or cold-adapted (ca) PIV3 (n = 37) with those of 28 adults administered 10(6) to 10(7) TCID50 of wild-type PIV3. The candidate...

Topics

Adaptation, Physiological
Adolescent
Adult
Animals
Antibodies, Viral
Cattle
Cold Temperature
Evaluation Studies as Topic
Humans
Mutation
Pan troglodytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parainfluenza Virus 3, Human

Paramyxoviridae Infections

Vaccines, Attenuated

Viral Vaccines

Virulence

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1650789
DOI: 10.1128/jcm.29.6.1175-1182.1991
PMCID: PMC269965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1650789-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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