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Article

A single-nucleotide polymorphism in a herpesvirus DNA polymerase is sufficient to cause lethal neurological disease.

The Journal of infectious diseases - 1 Jul 2009

Van de Walle Gerlinde R, Goupil Ryan, Wishon Cassandra, Damiani Armando, Perkins Gillian A, Osterrieder Nikolaus

Abstract excerpt

Epidemiological studies have shown that a single-nucleotide polymorphism in the equid herpesvirus type 1 DNA polymerase gene is associated with outbreaks of highly lethal neurological disease in horses. Reverse genetics experiments further demonstrated that a G(2254) A(2254) nucleotide mutation introduced in neurovirulent strain Ab4, which resulted in an asparagine for aspartic acid substitution (D(752) N(752)),...

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Identifiers

PMID: 19456260
DOI: 10.1086/599316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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