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Article

A point mutation in a herpesvirus polymerase determines neuropathogenicity.

PLoS pathogens - 1 Nov 2007

Goodman Laura B, Loregian Arianna, Perkins Gillian A, Nugent Josie, Buckles Elizabeth L, Mercorelli Beatrice, Kydd Julia H, Palù Giorgio, Smith Ken C, Osterrieder Nikolaus, Davis-Poynter Nicholas

Abstract excerpt

Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significantly associated with the neuropathogenic potential of naturally occurring strains. To test the hypothesis that this...

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Identifiers

PMID: 17997600
DOI: 10.1371/journal.ppat.0030160
PMCID: PMC2065875

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Source receipt: pubmed, retrieved 7 Sept 2026.

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