Glycoprotein gI of pseudorabies virus promotes cell fusion and virus spread via direct cell-to-cell transmission.

doi:10.1128/JVI.66.4.2316-2325.1992

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Article

Glycoprotein gI of pseudorabies virus promotes cell fusion and virus spread via direct cell-to-cell transmission.

Journal of virology - 1 Apr 1992

Zsak L, Zuckermann F, Sugg N, Ben-Porat T

Abstract excerpt

Mutants of pseudorabies virus defective in either glycoprotein gI or gIII are only slightly less virulent for mice and chickens than is wild-type virus, while mutants defective in both gI and gIII are avirulent. To clarify the reason for the lack of virulence of the gI- gIII- mutants, we have ana...

Topics

Animals
Antibodies, Viral
Cell Fusion
Cell Line
Herpesvirus 1, Suid
Immunization, Passive
Kinetics
Mice
Mutation
Neutralization Tests
Pseudorabies
Restriction Mapping
Viral Envelope Proteins
Viral Plaque Assay
Virulence
Virus Replication

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