Article
Haplotype identity between individuals who share a CFTR mutation allele "identical by descent": demonstration of the usefulness of the haplotype-sharing concept for gene mapping in real populations.
Human genetics - 1 Sept 1996
de Vries H G, van der Meulen M A, Rozen R, Halley D J, Scheffer H, ten Kate L P, Buys C H, te Meerman G J
Abstract excerpt
Cystic fibrosis (CF) patients with the A455E mutation, in both the French Canadian and the Dutch population, share a common haplotype over distances of up to 25 cM. French Canadian patients with the 621+1G-->T mutation share a common haplotype of more than 14 cM. In contrast, haplotypes containing the delta F508 mutation show haplotype identity over a much shorter genomic distance within and between populations,...
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