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Article

Growth Hormone Receptor Mutations Related to Individual Dwarfism.

International journal of molecular sciences - 10 May 2018

Lin Shudai, Li Congjun, Li Charles, Zhang Xiquan

Abstract excerpt

Growth hormone (GH) promotes body growth by binding with two GH receptors (GHRs) at the cell surface. GHRs interact with Janus kinase, signal transducers, and transcription activators to stimulate metabolic effects and insulin-like growth factor (IGF) synthesis. However, process dysfunctions in the GH⁻GHR⁻IGF-1 axis cause animal dwarfism. If, during the GH process, GHR is not successfully recognized and/or bound,...

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Source

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Identifiers

PMID: 29748515
DOI: 10.3390/ijms19051433
PMCID: PMC5983672

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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