Article
Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism.
The Journal of clinical investigation - 1 Mar 1991
Amselem S, Sobrier M L, Duquesnoy P, Rappaport R, Postel-Vinay M C, Gourmelen M, Dallapiccola B, Goossens M
Abstract excerpt
In addition to its classical effects on growth, growth hormone (GH) has been shown to have a number of other actions, all of which are initiated by an interaction with specific high affinity receptors present in a variety of tissues. Purification of a rabbit liver protein via its ability to bind GH has allowed the isolation of a cDNA encoding a putative human growth hormone receptor that belongs to a new class of...
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