Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens

doi:10.1186/1471-2164-13-306

Article

Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens

1 Jan 2012

Abstract excerpt

BACKGROUND: A deletion mutation in the growth hormone receptor (GHR) gene results in the inhibition of skeletal muscle growth and fat deposition in dwarf chickens. We used microarray techniques to determine microRNA (miRNA) and mRNA expression profiles of GHR in the skeletal muscles of 14-day-old embryos as well as 7-week-old deletion-type dwarf and normal-type chickens. Our aim was to elucidate the miRNA...

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