Oxidation resistant muteins of antileukoproteinase as potential therapeutic agents.

doi:10.1007/978-3-0348-7397-0_10

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Article

Oxidation resistant muteins of antileukoproteinase as potential therapeutic agents.

Agents and actions. Supplements - 1 Jan 1993

Steffens G J, Heinzel-Wieland R, Saunders D, Wolf B, Rudolphus A, Stolk J, Krarnps J A, Dijkman J A

Abstract excerpt

Native antileukoproteinase (ALP) and two oxidant resistant mutants ALP 242 and ALP 231 were synthesized by means of recombinant DNA technology. In the ALP 242 molecule the methionine residue located in the reactive centre of the binding loop is replaced by a leucine residue. In ALP 231 all four m...

Topics

Animals
Cathepsin G
Cathepsins
Cricetinae
Humans
Kinetics
Leukocyte Elastase
Lipopolysaccharides
Mesocricetus
Mutation
Oxidation-Reduction
Pancreatic Elastase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteinase Inhibitory Proteins, Secretory

Proteins

Pulmonary Emphysema

Reactive Oxygen Species

Recombinant Proteins

Serine Endopeptidases

Source

Open in PubMed

Identifiers

PMID: 8356918
DOI: 10.1007/978-3-0348-7397-0_10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8356918-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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