Article
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin.
Nature - 1 Jan 2000
Rosenberg S, Barr P J, Najarian R C, Hallewell R A
Abstract excerpt
Cumulative damage to lung tissue by leukocyte elastase is thought to be responsible for the development of pulmonary emphysema, an irreversible lung disease characterized by loss of lung elasticity. It is also thought to be involved in the rapidly developing and usually fatal adult respiratory distress syndrome. The primary defence against elastase damage is the anti-protease known as alpha 1-antitrypsin, a...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA
- Genes
- Humans
- Molecular Weight
- Mutation
- Oxidation-Reduction
- Plasmids
- Saccharomyces cerevisiae
- alpha 1-Antitrypsin